tag:blogger.com,1999:blog-61881353340370516882024-03-13T00:52:52.079-07:00First, Do No Harmksparrowmdhttp://www.blogger.com/profile/06136859539406777122noreply@blogger.comBlogger270125tag:blogger.com,1999:blog-6188135334037051688.post-86691218917649578842012-04-29T19:34:00.000-07:002012-12-30T21:27:43.107-08:00New Blog Address!My blog continues at a different address. Please come and visit anytime! Click <a href="http://www.ksparrowmd.com/category/kristen-sparrow-md-blog/">here</a>ksparrowmdhttp://www.blogger.com/profile/06136859539406777122noreply@blogger.com0tag:blogger.com,1999:blog-6188135334037051688.post-51047633807950862652012-04-29T07:22:00.000-07:002012-11-02T10:10:21.203-07:00Effects of acupuncture on stress-induced relapse to cocaine-seeking in ratsFor my current blog please click <a href="http://www.ksparrowmd.com/blog/">here. </a><br />
I can't evaluate the validity of this study, but wanted to cite it because they use the same point, Heart 7, as in this<a data-mce-href="http://ksparrowmd.com/alcohol-intake-and-acupuncture-in-rats/" href="http://ksparrowmd.com/alcohol-intake-and-acupuncture-in-rats/"> study,</a>
that looked at alcoholism in rats. In the clinic there is a decline in
alcohol consumption in patients that is quite pronounced. The two
studies look at different mechanisms for the craving and effect of
acupuncture, but I wanted to draw attention to the similarity.<br />
<blockquote>
<a data-mce-href="http://www.ncbi.nlm.nih.gov/pubmed/22453546" href="http://www.ncbi.nlm.nih.gov/pubmed/22453546">Effects of acupuncture on stress-induced relapse to cocaine-seeking in rats.</a><br />
Yoon SS, Yang EJ, Lee BH, Jang EY, Kim HY, Choi SM, Steffensen SC, Yang CH.Psychopharmacology (Berl). 2012 Mar 29.<br />
College of Oriental Medicine, Daegu Haany University, 165 Sang-Dong, Suseong-Gu, Daegu, 706-828, South Korea.<br />
Abstract<br />
RATIONALE:<br />
Cocaine
addiction is associated with high rates of relapse, and stress has been
identified as a major risk factor. We have previously demonstrated that
acupuncture reduces drug self-administration and dopamine release in
the nucleus accumbens (NAc), a brain structure implicated in
stress-induced reinstatement of drug-seeking behavior.<br />
OBJECTIVE:<br />
This
study was conducted to investigate the effects of acupuncture on
footshock-induced reinstatement of cocaine-seeking and the expression of
c-Fos and the transcription factor cAMP response element-binding
protein (CREB) in the NAc, used as markers of neuronal activation in
conditions of stress-induced reinstatement to cocaine.<br />
METHODS:<br />
Male
Sprague-Dawley rats were trained to self-administer cocaine (1.0 mg/kg)
for 14 days, followed by extinction and then footshock stress.
Acupuncture was applied at bilateral Shenmen (HT7) points for 1 min
after footshock stress.<br />
RESULTS AND CONCLUSIONS:<br />
Acute
footshock stress reinstated cocaine-seeking behavior and enhanced c-Fos
expression and phosphorylated CREB (pCREB) activation in the NAc shell
in cocaine pre-exposed rats. On the other hand, acupuncture at HT7, but
not at control point (LI5), markedly reduced reinstatement of
cocaine-seeking (86.5 % inhibition vs. control value), c-Fos expression
(81.7% inhibition), and pCREB activation (79.3% inhibition) in the NAc
shell. These results suggest that acupuncture attenuates stress-induced
relapse by regulating neuronal activation in the NAc shell.<br />
http://www.ncbi.nlm.nih.gov/pubmed/22453546</blockquote>
ksparrowmdhttp://www.blogger.com/profile/06136859539406777122noreply@blogger.com3tag:blogger.com,1999:blog-6188135334037051688.post-4351758039545680392012-04-28T14:40:00.003-07:002012-11-02T10:11:20.919-07:00Factors contributing to Therapeutic Effects Evaluated in Acupuncture Clinical Trials<br />
<br />
<br />
<header class="entry-header">
<h1 class="entry-title">
</h1>
<div class="entry-meta">
<span class="sep">For my most current blog posts please <a href="http://www.ksparrowmd.com/blog/">click here.</a> </span><br />
<span class="sep">Posted on </span><a href="http://ksparrowmd.com/factors-contributing-to-therapeutic-effects-evaluated-in-acupuncture-clinical-trials/" rel="bookmark" title="13:50"><time class="entry-date" datetime="2012-04-28T13:50:21+00:00" pubdate="">04/28/2012</time> </a>
</div>
<div class="entry-content">
<h2>
This is a comprehensive look at what is known about the different
types of acupuncture point stimulation. A very nice reference article
to have, and has free <a href="http://www.trialsjournal.com/content/13/1/42/abstract">access to the article</a> online.</h2>
<br />
<blockquote>
<h2>
<a href="http://www.ncbi.nlm.nih.gov/pubmed/22520963">Factors contributing to therapeutic effects evaluated in acupuncture clinical trials.</a><br />
<i>Shi GX, Yang XM, Liu CZ, Wang LP.</i><br />
<i>Trials. 2012 Apr 21;13(1):42.</i><br />
Abstract
ABSTRACT: Acupuncture treatment has been widely used for many
conditions, while results of the increasing numbers of randomized trials
and systematic reviews remain controversial. Acupuncture is a complex
intervention of both specific and non-specific factors associated with
therapeutic benefit. Apart from needle insertion, issues such as
needling sensation, psychological factors, acupoint specificity,
acupuncture manipulation, and needle duration also have relevant
influences on the therapeutic effects of acupuncture. Taking these
factors into consideration would have considerable implications for the
design and interpretation of clinical trials.</h2>
</blockquote>
</div>
</header>ksparrowmdhttp://www.blogger.com/profile/06136859539406777122noreply@blogger.com0tag:blogger.com,1999:blog-6188135334037051688.post-34485814562547468252012-04-28T13:28:00.001-07:002012-11-02T10:11:58.194-07:00My New HRV System! Viva Vivosense!For my most recent blog posts, please<a href="http://www.ksparrowmd.com/blog/"> click here. </a><br />
This is what my new analysis system data looks like on the screen. One can customize which parameters to look at, what window length to use, but most important, it has an extremely sophisticated, automatic method to manage artifact, which is the bane of HRV analysis. The company website is http://vivonoetics.com<br />
This data is from a patient who is a classic "responder." She had moderately severe panic attacks on the freeway which were basically eliminated with acupuncture. She also gets very "blissed out" with every treatment and so comes often just because it feels so therapeutic to her. If you notice in the top green linline there are gray areas. These represent areas that were removed due to artifact. She had quite a few! the next line is LFR/HFR during the session. As you can see it goes down, which is what we would expect with a responder. The next line is Sample Entropy, which tends to go up, also what you would expect. And the last is pnn50 trend which increases as one would expect with increasing HRV with acupuncture.<br />
<br />
<img alt="" src="data:image/png;base64,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" />ksparrowmdhttp://www.blogger.com/profile/06136859539406777122noreply@blogger.com0tag:blogger.com,1999:blog-6188135334037051688.post-38796120564718772172012-04-25T21:10:00.000-07:002013-02-08T21:27:21.119-08:00Napadow Paper Linking ANS and fMRI and acupuncture stimuli<br />
<header class="entry-header">
<h1 class="entry-title">
Napadow Paper Linking ANS and fMRI and acupuncture stimuli</h1>
<div class="entry-meta">
<span class="sep">Posted on </span><a href="http://ksparrowmd.com/napadow-paper-linking-ans-and-fmri-and-acupuncture-stimulia/" rel="bookmark" title="20:52"><time class="entry-date" datetime="2012-04-25T20:52:55+00:00" pubdate="">04/25/2012</time> </a>
</div>
<div class="entry-content">
I’ve been making my way through the Napadow paper mentioned<a href="http://ksparrowmd.com/autonomic-nervous-system-and-acupuncture-brain-mapping-napadow/"> here</a> and<a href="http://ksparrowmd.com/me-got-a-mention-in-napadow-paper/"> here</a>.
It is a remarkable piece of research because it not only links
individual acupuncture points to their fMRI profile, but also to their
ANS response and to the subjective pain response evoked. (More blog posts and practice info <a href="http://www.ksparrowmd.com/">here</a>.) Here is the
final paragraph.<br />
<blockquote>
In conclusion, our approach allowed us to link ANS and<br />
fMRI response in order to infer potential control brain circuitry
underlying different autonomic responses to acupuncture stimuli at
different acupoints. Our results<br />
suggest that different sub-regions of the brain circuitry<br />
responding to acupuncture appear to be associated with<br />
different ANS outflow responses to needle stimuli and<br />
may result from different sensations elicited by stimuli at<br />
different bodily locations. This study applied er-fMRI to<br />
link brain and ANS response to acupuncture, and future<br />
studies should explore how this central autonomic network<br />
response to acupuncture influences clinical<br />
outcomes.</blockquote>
</div>
</header>ksparrowmdhttp://www.blogger.com/profile/06136859539406777122noreply@blogger.com0tag:blogger.com,1999:blog-6188135334037051688.post-33707882737648095962012-04-24T15:59:00.001-07:002012-04-24T15:59:48.315-07:00Me! Got a mention in Napadow Paper<header class="entry-header">
<h1 class="entry-title">
Me! Got a mention in Napadow Paper</h1>
<div class="entry-meta">
<span class="sep">Posted on </span><a href="http://ksparrowmd.com/me-got-a-mention-in-napadow-paper/" rel="bookmark" title="15:57"><time class="entry-date" datetime="2012-04-24T15:57:26+00:00" pubdate="">04/24/2012</time> </a>
</div>
<div class="entry-content">
Shameless self promotion. I will copy the paragraph from <a href="http://www.ncbi.nlm.nih.gov/pubmed/22504841">Vitaly Napadow’s</a> most recent paper (discussed <a href="http://ksparrowmd.com/autonomic-nervous-system-and-acupuncture-brain-mapping-napadow/">here</a>) with a mention of MY study. The link to MY study<a href="http://ksparrowmd.com/research/2007-journal-of-medical-acupuncture-hrv-in-the-acupunctureclinic/"> here</a>…;<br />
<br />
<blockquote>
In this study, we have, for the first time, applied er-fMRI<br />
to evaluate the brain correlates of acupuncture stimulation.<br />
This approach has allowed us to link brain response to acupuncture<br />
stimulation with synchronous ANS response,<br />
thereby determining the brain circuitry underlying different<br />
autonomic outflow patterns—e.g., decelerative (HR ) versus<br />
accelerative (HRþ) HR response. Different autonomic<br />
outflow patterns may have meaningful implications on clinical<br />
response to acupuncture [Sparrow, 2007] and we<br />
hypothesized that different psychophysiological response<br />
patterns, denoted by different ANS outflows, result from<br />
different brain responses to acupuncture stimuli.</blockquote>
</div>
</header>ksparrowmdhttp://www.blogger.com/profile/06136859539406777122noreply@blogger.com0tag:blogger.com,1999:blog-6188135334037051688.post-65574695314843678752012-04-22T10:42:00.000-07:002012-04-22T10:42:00.188-07:00Electroacupuncture Stimulates Neuroproliferation In Baby RatsThe authors conclude that this gives some theoretical basis for using acupuncture for cerebral injury in children. I wonder if it could also give some theoretical basis for use in clinically depressed patients. In this article from the <a href="http://www.nytimes.com/2012/04/22/magazine/the-science-and-history-of-treating-depression.html?_r=2&ref=health">NYTimes</a> discussing Prozac, Serotonin and the mechanisms behind using SSRI's in depression, they make the point that there may be some neuronal death involved in depression also. So maybe there is a case for acupuncture here also? It is a long, but very interesting article, if you're interested in depression and anti-depressants. The journal article on animals follows.<br />
<div itemprop="articleBody">
<br />
<blockquote class="tr_bq">
"Could there be a connection between emotion and neuronal birth in the hippocampus?"</blockquote>
</div>
<div itemprop="articleBody">
<br /></div>
<div itemprop="articleBody">
</div>
<blockquote class="tr_bq">
"In 2011, Hen and his colleagues repeated these studies with depressed primates. In monkeys, chronic stress produces a syndrome with symptoms remarkably similar to some forms of human depression. Even more strikingly than mice, stressed monkeys lose interest in pleasure and become lethargic. When Hen measured neuron birth in the hippocampi in depressed monkeys, it was low. When he gave the monkeys antidepressants, the depressed symptoms abated and neuron birth resumed. Blocking the growth of nerve cells made Prozac ineffective."</blockquote>
<a href="http://www.ncbi.nlm.nih.gov/pubmed/20852908">http://www.ncbi.nlm.nih.gov/pubmed/20852908</a><br />
Neurol Sci. 2011 Jun;32(3):369-74. Epub 2010 Sep 18.<br />
Electroacupuncture enhances cell proliferation and neuronal differentiation in young rat brains.<br />
Gao J, Wang S, Wang X, Zhu C.<br />
Source<br />
Department of Pediatrics, The Third Affiliated Hospital of Zhengzhou University, Kangfuqain Street 7, Zhengzhou 450052, China.<br />
Abstract<br />
To investigate the effect of electroacupuncture on cell proliferation and differentiation in young rat hippocampus, postnatal day-14 rats were assigned randomly to control, ketamine anesthesia, nonacupoint, or acupoint electroacupuncture groups. Electroacupuncture was applied at bilateral acupoints (Quchi, Waiguan, Huantiao, and Zusanli) 30 min daily for 7 successive days. The proliferation and neuronal differentiation of proliferated surviving cells in the dentate gyrus were evaluated at 4 weeks after last stimulation. The stimulatory effect of electroacupuncture on cell proliferation had a long-lasting effect, as indicated by the increased phosphor-histone H3-positive cells. The number of proliferated and survival cells, indicated by BrdU labeling, was highest in the electroacupuncture group.<strong> The number of newly differentiated neurons, as indicated by BrdU/NeuN double labeling, was significantly higher in the electroacupuncture group than in any of the other groups. </strong>This finding provides a theoretical basis for the clinical application of acupuncture to cerebral injury rehabilitation in children.ksparrowmdhttp://www.blogger.com/profile/06136859539406777122noreply@blogger.com0tag:blogger.com,1999:blog-6188135334037051688.post-64080854782735645892012-04-21T09:44:00.001-07:002012-04-21T10:27:25.719-07:00Brain Chemistry Involved in Electroacupuncture AnalgesiaA nice study from University of Maryland from Lixing Lao who does excellent all around work, but is particularly interested in using rat arthritis models to explore the mechanisms of acupuncture. I've discussed his work<a href="http://ksparrowmd.blogspot.com/2012/02/spinal-serotonin-and-electroacupuncture.html"> here</a> and <a href="http://ksparrowmd.blogspot.com/2011/10/more-isamslixing-lao-presenting-recent.html">here</a> among other citations. The abstract is copied in its entirety here.<br />
<br />
<a href="http://www.ncbi.nlm.nih.gov/pubmed/21565329">http://www.ncbi.nlm.nih.gov/pubmed/21565329</a><br />
Brain Res. 2011 Jun 13;1395:38-45. Epub 2011 Apr 28.<br />
Rostral ventromedial medulla μ, but not κ, opioid receptors are involved in electroacupuncture anti-hyperalgesia in an inflammatory pain rat model.<br />
Zhang Y, Li A, Lao L, Xin J, Ren K, Berman BM, Zhang RX.<br />
<br />
Source<br />
Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA.<br />
<br />
Abstract<br />
It has been reported that intracerebroventricular injection of a μ receptor antagonist blocked 2 but not 100Hz electroacupuncture (EA)-produced analgesia in an uninjured animal model. Because persistent pain changes neural response to external stimulation, we hypothesized that the mechanisms of EA anti-hyperalgesia may be different in persistent pain than in health. Hyperalgesia, decreased paw withdrawal latency (PWL) to a noxious thermal stimulus, was induced by subcutaneously injecting complete Freund's adjuvant (CFA) into the hind paws of rats. Selective antagonists against μ (CTOP: D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-ThrNH2, 6.25 nmol) and κ (Nor-BIN: nor-binaltorphimine, 10 nmol) opioid receptors were infused into the rostral ventromedial medulla (RVM) 10 min before a 30-min EA treatment at acupoint Huantiao (GB30) 1h 30 min post-CFA. PWL was measured before and 2.5 post-CFA. Both 10 Hz and 100 Hz EA-produced anti-hyperalgesia were blocked by intra-RVM μ, but not κ, receptor antagonists. Double immunofluorescence staining demonstrated that μ receptor-containing neurons were GABAnergic and that GABAa receptor-containing neurons were serotonergic in the RVM. The results demonstrated an involvement of RVM μ, but not κ, receptors in EA-produced anti-hyperalgesia. In summary, EA may induce release of endogenous endomorphins that activate μ opioid receptors in GABAnergic neurons to suppress the release of GABA. This removes the tonic inhibition of GABA on serotonergic neurons in the RVM, and activation of these serotonergic neurons inhibits pain. EA may be used as complementary treatment for inflammatory pain.ksparrowmdhttp://www.blogger.com/profile/06136859539406777122noreply@blogger.com0tag:blogger.com,1999:blog-6188135334037051688.post-32253296619343054742012-04-21T09:08:00.006-07:002012-04-21T09:32:58.807-07:00Autonomic Nervous System and Acupuncture: Brain Mapping, NapadowVitaly Napadow has another paper looking at the ANS (Autonomic Nervous System) and acupuncture in conjunction with brain imaging. I've highlighted some of Napadow's work <a href="http://ksparrowmd.blogspot.com/2012/01/brain-circuitry-and-heart-rate.html">here</a> and <a href="http://ksparrowmd.blogspot.com/2011/10/differences-in-cortical-response-to.html">here</a>, he shares my interest in the ANS and acupuncture. (If you put his name in the search field of this blog you'll find some of his other work.) In this study, they look at different acupuncture points and correlate them with changes in Heart Rate (HR) and Skin Conductance (SC). They then look at the areas of the brain that are activated.<br /><br />Hum Brain Mapp. 2012 Apr 14. doi: 10.1002/hbm.22091. [Epub ahead of print<a href="http://www.ncbi.nlm.nih.gov/pubmed/22504841">]Brain correlates of phasic<br />autonomic response to acupuncture stimulation:</a> An event-related fMRI<br />study.<em><span style="font-size:85%;">Napadow V, Lee J, Kim J, Cina S, Maeda Y, Barbieri R,<br />Harris RE, Kettner N, Park K.SourceMartinos Center for Biomedical Imaging,<br />Department of Radiology, Massachusetts General Hospital, Charlestown,<br />Massachusetts; Department of Radiology, Logan College of Chiropractic,<br />Chesterfield, Missouri. </span></em><a href="mailto:vitaly@nmr.mgh.harvard.edu.Abstract"><em><span style="font-size:85%;">vitaly@nmr.mgh.harvard.edu.Abstract</span></em></a><br /><br />Autonomic nervous system (ANS) response to acupuncture has been<br />investigated by multiple studies; however, the brain circuitry underlying this<br />response is not well understood. We applied event-related fMRI (er-fMRI) in<br />conjunction with ANS recording (heart rate, HR; skin conductance response, SCR).<br />Brief manual acupuncture stimuli were delivered at acupoints ST36 and SP9, while<br />sham stimuli were delivered at control location, SH1. Acupuncture produced<br />activation in S2, insula, and mid-cingulate cortex, and deactivation in default<br />mode network (DMN) areas. On average, HR deceleration (HR-) and SCR were noted<br />following both real and sham acupuncture, though magnitude of response was<br />greater following real acupuncture and inter-subject magnitude of response<br />correlated with evoked sensation intensity. Acupuncture events with strong SCR<br />also produced greater anterior insula activation than without SCR. Moreover,<br />acupuncture at SP9, which produced greater SCR, also produced stronger sharp<br />pain sensation, and greater anterior insula activation. Conversely,<br />acupuncture-induced HR- was associated with greater DMN deactivation.<br />Between-event correlation demonstrated that this association was strongest for<br />ST36, which also produced more robust HR-. In fact, DMN deactivation was<br />significantly more pronounced across acupuncture stimuli producing HR-, versus<br />those events characterized by acceleration (HR+). Thus, differential brain<br />response underlying acupuncture stimuli may be related to differential autonomic<br />outflows and may result from heterogeneity in evoked sensations. Our er-fMRI<br />approach suggests that ANS response to acupuncture, consistent with previously<br />characterized orienting and startle/defense responses, arises from activity<br />within distinct subregions of the more general brain circuitry responding to<br />acupuncture stimuli. Hum Brain Mapp , 2012ksparrowmdhttp://www.blogger.com/profile/06136859539406777122noreply@blogger.com0tag:blogger.com,1999:blog-6188135334037051688.post-3382143345285045882012-04-21T07:39:00.006-07:002012-04-21T09:04:43.452-07:00NYTimes Book Review: How Doctors and Patients Do Harm<div>If you would like to go to whole interview with this doctor, click on the title. I excerpt only a small portion. Information about my practice <a href="http://well.blogs.nytimes.com/2012/04/20/how-doctors-and-patients-do-harm/?ref=health">here.</a></div><div> </div><div><a href="http://well.blogs.nytimes.com/2012/04/20/how-doctors-and-patients-do-harm/?ref=health">How Doctors and Patients Do Harm</a></div><div> </div><div><blockquote><p> How Doctors and Patients Do HarmBy TARA PARKER-POPEChristopher T. Martin Dr. Otis Brawley, chief medical officer for the American Cancer Society. Just how broken is the United States health care system? Dr. Otis Brawley, chief medical officer for the American Cancer Society, paints a grim picture in his new book “How We Do Harm: A Doctor Breaks Ranks About Being Sick In America’’ (St. Martin’s Press).If the title alone doesn’t clue you in, the reader quickly discovers that Dr. Brawley is determined to make everyone as uncomfortable as possible about the flaws, inconsistencies and inequities that are rampant in American medical care... I am trying to get folks, through this book, to talk a little more about rational use of health care and realize that we are actually hurting people with overtreatment. Health care needs to be consumed in a wiser way that is much more concerned about allegiance to the science. We need to be more concerned about the welfare of our patients. There was a recent report, the 45 tests we do too much, that I was thrilled to see. People are starting to realize that we need to be a little wiser in our use of health care.</p><blockquote><p> </p></blockquote></blockquote></div>ksparrowmdhttp://www.blogger.com/profile/06136859539406777122noreply@blogger.com0tag:blogger.com,1999:blog-6188135334037051688.post-76743405579585903912012-04-19T08:58:00.004-07:002012-04-19T11:22:05.520-07:00Genentech Tries New Tack on Shelved Breast Cancer Drug AvastinThis is an article from the San Francisco Chronicle about "a new kind of study" Genentech is going to try with it's discredited drug, Avastin. They will be looking for a DNA profile of patients who have responded to the drug. I bring this to my readers attention because it is an example of the sort of departure from the scientific method we're seeing in medicine. Their evidence from this study would clearly be anecdotal, but since they have deep pockets, they may be able to find something useful there. But it also shows how individual patients who were successfully treated are recruited and interviewed by these companies to make the case for the drugs. We have to remember that these are anecdotal results from these individuals. If a patient had a positive result from homeopathy or laetrile, and stood before congress to plea for insurance coverage for that treatment, they would be laughed out of the theater. Controlled studies are in place for a reason, and we have to willing to accept their results for better or worse even though we're surprised or skeptical as with <a href="http://ksparrowmd.blogspot.com/2012/01/prostrate-screening-update-first-do-no.html">PSA testing</a>, or <a href="http://ksparrowmd.blogspot.com/2012/04/doctor-panels-recommending-fewer-tests.html">antibiotics.</a><br />I wrote about<a href="http://ksparrowmd.blogspot.com/2011/11/approval-for-avastin-for-breast-cancer.html"> Avastin </a>here. Info on my practice<a href="http://www.ksparrowmd.com/"> here.<br /><br /></a><a href="http://sfgate.com/cgi-bin/article.cgi?f=/c/a/2012/04/14/MNV61O0Q4D.DTL"></a><blockquote><a href="http://sfgate.com/cgi-bin/article.cgi?f=/c/a/2012/04/14/MNV61O0Q4D.DTL">Online study of Avastin breast cancer patients<br /></a><br />Victoria Colliver<br /><br />Saturday, April 14, 2012<br /><br />South San Francisco's Genentech has teamed up with personal genetics company 23andMe for a new kind of study - one that doesn't require patients to find a clinical trial center or make frequent visits to a doctor's office.<br /><br />The Bay Area companies are initiating an online effort to recruit 1,000 patients with metastatic breast cancer who have taken Genentech's Avastin, a drug that had its approval for breast cancer revoked last year over safety and efficacy concerns.<br /><br />Genentech officials hope to find genetic markers in those patients that could identify who might respond better to the drug than others. They say the study is not necessarily designed to get the drug back on the market for breast cancer, but to figure out if Avastin helps certain types of breast cancer patients. Such research could ultimately lead to its reapproval...<br />Critics say the online study appears to be biased toward women who have done well on Avastin, but its sponsors say they're simply trying to find common factors in a large group of patients that could be tested in more traditional clinical trials...<br /><br />The U.S. Food and Drug Administration revoked its approval of Avastin for breast cancer after studies showed the drug caused life-threatening side effects such as bleeding and heart failure. Studies also found it failed to help patients with metastatic breast cancer live longer...<br /></blockquote>Please click on the title if you'd like to read the whole article.ksparrowmdhttp://www.blogger.com/profile/06136859539406777122noreply@blogger.com0tag:blogger.com,1999:blog-6188135334037051688.post-81754175251641435882012-04-17T15:01:00.004-07:002012-04-17T15:17:34.642-07:00Cancer Screening: Opinions from the Field<div class="timestamp">I'm sure everyone is sick of this <a href="http://ksparrowmd.blogspot.com/2012/04/doctor-panels-recommending-fewer-tests.html">topic</a>, but I thought I would share the take of two physicians who have had a careful look at the recent recommendations. I've redacted heavily and just left the main conclusions. For info on my practice, please click <a href="http://www.ksparrowmd.com/">here.</a><br /><br /></div><blockquote><div class="timestamp">April 16, 2012</div> <h1><a href="http://www.nytimes.com/2012/04/17/health/views/endless-screenings-dont-bring-everlasting-health.html?_r=1&ref=health&pagewanted=print">Endless Screenings Don’t Bring Everlasting Health</a></h1> <span itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><h6 itemprop="name" class="byline">By LISA M. SCHWARTZ, M.D. and STEVEN WOLOSHIN, M.D.</h6></span><p itemprop="articleBody"> <span style="font-weight: bold;">Since there is no reliable way to know whether a screening-detected cancer represents overdiagnosis, most people seek treatment. People on the receiving end of overdiagnosis can only be harmed — sometimes seriously — by unnecessary surgery, radiation and </span><a style="font-weight: bold;" href="http://topics.nytimes.com/top/news/health/diseasesconditionsandhealthtopics/chemotherapy/index.html?inline=nyt-classifier" title="Recent and archival health news about chemotherapy." class="meta-classifier">chemotherapy</a><span style="font-weight: bold;">. </span>While it’s hard to precisely estimate the amount of overdiagnosis that occurs, most experts agree that it’s an inevitable consequence of screening. </p> <p itemprop="articleBody"> <span style="font-weight: bold;">The bottom line is that while screening may help some people avoid a cancer death, it will harm many others...<br /></span></p><p itemprop="articleBody"> As noted by the task force, the harms of P.S.A. screening probably outweigh the benefits, which actually are uncertain. None were observed in an American trial, and just a small benefit was found in a European trial. The test results in a disturbing amount of overdiagnosis. </p> <p itemprop="articleBody"> For women at average risk, mammography is a close call. Trials suggest that there are about one to three fewer deaths for every 1,000 women screened over 10 years (the benefit increases with age). <span style="font-weight: bold;">But there is substantial overdiagnosis — as many as 10 unnecessary diagnoses per death avoided. Rather than persuading women to be screened, we should help them be informed.</span> </p> <p itemprop="articleBody"> <span style="font-weight: bold;">For </span><a style="font-weight: bold;" href="http://health.nytimes.com/health/guides/specialtopic/colon-cancer-screening/overview.html?inline=nyt-classifier" title="In-depth reference and news articles about Colon cancer screening." class="meta-classifier">colon cancer screening</a><span style="font-weight: bold;">, </span><a style="font-weight: bold;" href="http://www.nejm.org/doi/full/10.1056/NEJM199305133281901">the benefit of the fecal occult blood test outweighs the harms</a><span style="font-weight: bold;">. (Surprisingly, colonoscopy hasn’t been evaluated yet in a randomized trial.) There are about three fewer </span><a style="font-weight: bold;" href="http://health.nytimes.com/health/guides/disease/colon-cancer/overview.html?inline=nyt-classifier" title="In-depth reference and news articles about Colon Cancer." class="meta-classifier">colon cancer</a><span style="font-weight: bold;"> deaths per 1,000 people screened over 13 years, without a lot of false alarms requiring invasive procedures. There has been no evidence of cancer overdiagnosis with this test. </span></p> <p itemprop="articleBody"> <span style="font-weight: bold;">For people at high risk of lung cancer because of heavy </span><a style="font-weight: bold;" href="http://health.nytimes.com/health/guides/specialtopic/smoking-and-smokeless-tobacco/overview.html?inline=nyt-classifier" title="In-depth reference and news articles about Smoking and smokeless tobacco." class="meta-classifier">smoking</a><span style="font-weight: bold;">, </span><a style="font-weight: bold;" href="http://www.nejm.org/doi/full/10.1056/NEJMoa1102873">the benefits of CT screening outweigh harms</a><span style="font-weight: bold;"> if it is done at highly skilled centers.</span> </p></blockquote><p itemprop="articleBody"><br /></p>ksparrowmdhttp://www.blogger.com/profile/06136859539406777122noreply@blogger.com0tag:blogger.com,1999:blog-6188135334037051688.post-41619051021376040372012-04-14T09:57:00.003-07:002012-04-14T10:04:11.630-07:00Acupuncture suppresses bladder activity: Animal StudyThis is an interesting study performed in rats showing that the inhibitory effect on micturition (urination) by acupuncture takes place in the brainstem. This is surprising to me, since I would have thought it was more of a spinal reflex/gating mechanism. (info on my practice<a href="http://www.ksparrowmd.com"> here</a>)<br /><a href="Neurosci%20Res.%202012%20Jan;72%281%29:43-9.%20Epub%202011%20Oct%204."></a><blockquote><a style="font-weight: bold;" href="Neurosci%20Res.%202012%20Jan;72%281%29:43-9.%20Epub%202011%20Oct%204.">Acupuncture of the sacral vertebrae suppresses bladder activity and bladder activity-related neurons in the brainstem micturition center.</a><br /><span style="font-size:85%;"><span style="font-style: italic;">Wang H, Tanaka Y, Kawauchi A, Miki T, Kayama Y, Koyama Y.</span></span><br /><span style="font-size:85%;"><span style="font-style: italic;">Department of Physiology, Guiyang College of Traditional Chinese Medicine, Guiyang 550001, China</span></span><br />Acupuncture of the sacral vertebrae has therapeutic effects in patients with overactive bladders. The mechanism of these effects, however, remains unclear. The present study, using urethane-anesthetized rats, investigated the effects of acupuncture stimulation of the sacral vertebrae on bladder activity and bladder activity-related neurons in and around Barrington's nucleus. In 95 of 147 trials (64.6%), acupuncture stimulation of the sacral vertebrae for 1 min suppressed bladder contraction for 27-2347s...These findings suggest that acupuncture stimulation of the sacral vertebrae suppresses bladder contraction and changes the firing properties of bladder activity-related neurons in and around Barrington's nucleus, and that these changes are mediated by GABAergic systems.</blockquote>ksparrowmdhttp://www.blogger.com/profile/06136859539406777122noreply@blogger.com1tag:blogger.com,1999:blog-6188135334037051688.post-59906430438680984412012-04-07T14:44:00.007-07:002012-04-08T09:31:53.364-07:00Acupuncture, HRV and InsomniaAnother HRV study by Litscher and his team in China. A previous post, <a href="http://ksparrowmd.blogspot.com/2012/04/hrv-and-auricular-acupuncture-in-rats.html">"Part I" described HRV analysis in rats for seizures</a>. This article explores acupuncture in patients with insomnia. Unfortunately they don't report on how the patients' insomnia symptoms responded(?) There is a link to the full paper<a href="http://www.hindawi.com/journals/ecam/2012/916085/"> here.</a> At the end of the journal article in the discussion they say<br /><span style="font-weight: bold;"></span><blockquote><span style="font-weight: bold;">The significance of our data indicates that maybe differences exist between those patients who respond to acupuncture insomnia therapy and those that do not. Further research into the use of electrocardiogram and other physiological parameters to stratify response to acupuncture therapeutic interventions is warranted.</span></blockquote>This is exactly the point of my own <a href="http://ksparrowmd.com/research/">research;</a> to try to better guide treatment by adding HRV outcomes to symptomatic outcomes. Litscher merely mentions this as a possibility, but does not reveal how his data might show this.<br />He also says in the article that he chose to do single point acupuncture (Heart 7),unusual in clinical practice, so that he would have a point of comparison for future studies with single point auricular acupuncture.<br />One final point is that he found no change in LFR/HFR ratio during acupuncture, which is counter to my own findings and those of <a href="http://www.ncbi.nlm.nih.gov/pubmed/18209515">Backer</a>, but consistent with those of <a href="http://ksparrowmd.blogspot.com/2012/03/hrv-and-acupuncture-study-isams-huang.html">Huang</a>. As always, "more study needed."<br />More on my practice <a href="http://www.ksparrowmd.com/">here.</a><br /><br /><br /><a href="https://www.google.com/accounts/NewAccount?service=mail&continue=http://mail.google.com/mail/e-11-9ebb10326732d30efaf1b328669a4-80c039dfe40a6d05f57082f4bed35306cad8e32e&type=2"><span style="font-weight: bold;"></span></a><blockquote><a href="https://www.google.com/accounts/NewAccount?service=mail&continue=http://mail.google.com/mail/e-11-9ebb10326732d30efaf1b328669a4-80c039dfe40a6d05f57082f4bed35306cad8e32e&type=2"><span style="font-weight: bold;">Sino-European transcontinental basic and clinical high-tech acupuncture studies-part 2: acute stimulation effects on heart rate and its variability in patients with insomnia.</span></a><br /><span style="font-size:85%;"><span style="font-style: italic;">Litscher G, Cheng G, Cheng W, Wang L, Niu Q, Feng X, Gaischek I, Kuang H.</span> <span style="font-style: italic;">Evid Based Complement Alternat Med. 2012;2012:916085. Epub 2012 Mar 4.</span></span><br /><br /><span style="font-size:85%;"><span style="font-style: italic;">Research Unit of Biomedical Engineering in Anesthesia and Intensive Care Medicine and Stronach Research Unit for Complementary and Integrative Laser Medicine, TCM Research Center Graz, Medical University of Graz, 8036 Graz, Austria.</span></span><br /><br />This second part of a series of Sino-European high-tech acupuncture studies describes the first clinical transcontinental teleacupuncture measurements in patients with insomnia. Heart rate (HR) and heart rate variability (HRV) measurements in 28 patients (mean age ± SD: 41.9 ± 14.6 years) were performed under standardized conditions in Harbin, China, and the data analysis was performed in Graz, Austria. Similar to the first part of the series, the electrocardiograms (ECGs) were recorded by an HRV Medilog AR12 system during acupuncture of the Shenmen point (HT7) on the left hand. HR decreased significantly (P < 0.001) during and after acupuncture stimulation of the HT7 acupuncture point. Total HRV increased significantly (P < 0.05) immediately after acupuncture stimulation, but there was no long-lasting effect. The values of the low-frequency (LF) and high-frequency (HF) band increased significantly after the stimulation compared to baseline values;<span style="font-weight: bold;"> however, the LF/HF ratio showed no significant changes.</span> Together with the results of previous studies, the present results can serve as a solid basis for further development of acupressure or acupuncture stimulation equipment for complementary use in treating insomnia.<br /><br /></blockquote>ksparrowmdhttp://www.blogger.com/profile/06136859539406777122noreply@blogger.com0tag:blogger.com,1999:blog-6188135334037051688.post-59298368991769597672012-04-06T12:39:00.000-07:002012-04-06T12:40:52.989-07:00Doctor Panels Recommending Fewer Tests for Patients<header class="entry-header">As a follow up to a previous post about patients opting for less treatment, this article reports on the latest guidelines from 9 specialty boards, recommending fewer tests, and urging patients to refuse them if offered (!) This blog may become obsolete! Ojala, as we would say in Spain. Looking through the list, there seems to be an admission that sometimes even though the tests themselves may not be risky, the increased likelihood of false positives leading to more intervention is not a good thing.<div class="entry-content"> <p>Looking at the <a href="http://choosingwisely.org/?page_id=13">report</a> what they did is ask each specialty to come up with 5 treatments or tests that should be given extra thought. A quick read through reveals some of the following. 1) No antibiotics for simple rhinosinusitis 2) No imaging for low back pain less than 6 weeks duration 3) No pap smears for women under 21 years of age or post hysterectomy 4) Cardiac stress tests should be needed not routine 5) No CT nor MRI for simple sycope nor for headache 6) For GERD,use the lowest dose of Proton Pump Inhibitors possible 7) Less imaging for early stage breast and prostate cancer 8) <strong> Avoid nonsteroidal anti-inflammatory drugs (NSAIDS) in individuals with hypertension or heart failure or Chronic Kidney Disease of all causes, including diabetes. (did not know this!!) </strong>9) Avoid Cardiac Imaging (nuclear and CT) in low risk patients<strong><br /></strong></p> <p>More on my practice <a href="http://www.ksparrowmd.com">here. </a><br /></p> <blockquote><p> <a href="http://www.nytimes.com/2012/04/04/health/doctor-panels-urge-fewer-routine-tests.html?ref=health">Doctor Panels Recommend Fewer Tests for Patients</a><br />By RONI CARYN RABIN</p> <p>In a move likely to alter treatment standards in hospitals and doctors’ offices nationwide, a group of nine medical specialty boards plans to recommend on Wednesday that doctors perform 45 common tests and procedures less often, and to urge patients to question these services if they are offered. Eight other specialty boards are preparing to follow suit with additional lists of procedures their members should perform far less often.</p> <p><strong>The recommendations represent an unusually frank acknowledgment by physicians that many profitable tests and procedures are performed unnecessarily and may harm patients.</strong> <strong>By some estimates, unnecessary treatment constitutes one-third of medical spending in the United States.</strong></p> <p><strong>“Overuse is one of the most serious crises in American medicine,” said Dr. Lawrence Smith, physician-in-chief at North Shore-LIJ Health System and dean of the Hofstra North Shore-LIJ School of Medicine, who was not involved in the initiative. “Many people have thought that the organizations most resistant to this idea would be the specialty organizations, so this is a very powerful message.”</strong></p></blockquote> </div></header>ksparrowmdhttp://www.blogger.com/profile/06136859539406777122noreply@blogger.com0tag:blogger.com,1999:blog-6188135334037051688.post-12796894592181226362012-04-06T12:13:00.000-07:002012-04-06T12:14:38.039-07:00Opioid Use for Abdominal Pain, A Bad Idea<header class="entry-header"><span class="sep"></span>In an article from Anesthesiology News <a href="http://anesthesiologynews.com/ViewArticle.aspx?d=In%2bBrief&d_id=220&i=March+2012&i_id=820&a_id=20325">“Opioid Use for Abdominal Pain Sees Recent Spike”</a> they point out that from 1997 to 2008, opioid prescriptions for chronic abdominal pain more than doubled in the U.S. (study from Clinical Grastroenterology and Hepatology (2011;9:1078-1085). This points to an increasing problem I see in my clinic, that opioids are handed out because they are “stronger,” not only for musculoskeletal pain, but for conditions where they are clearly contraindicated like gastrointestinal problems. In the case of musculoskeletal pain, opioids can be of very limited value, though it varies case to case. With their danger of addiction and gastrointestinal and cognitive side effects, the threshold for prescribing should be high. More on my practice <a href="http://www.ksparrowmd.com/">here.</a><div class="entry-content"> <p> </p> <blockquote><p><strong>The investigators noted that this increase in opioid prescriptions has been problematic, in part because no study has shown opioids to be effective for treating chronic abdominal pain. When used over long periods of time, opioids may worsen other gastrointestinal symptoms, such as constipation, nausea and vomiting.</strong></p> <p>The growing use of opioids to treat “persistent abdominal pain highlights the growing challenges clinicians face trying to manage chronic illness without the time, infrastructure and incentives needed to take the integrated approach that experts suggest,” said lead study author Spencer D. Dorn, MD, MPH, assistant professor of medicine at the University of North Carolina at Chapel Hill, in a statement.</p></blockquote> </div></header>ksparrowmdhttp://www.blogger.com/profile/06136859539406777122noreply@blogger.com0tag:blogger.com,1999:blog-6188135334037051688.post-9283937772377078482012-04-06T12:03:00.002-07:002012-04-06T12:13:02.150-07:00HRV and Auricular Acupuncture in Rats<h1 class="entry-title"><a href="http://ksparrowmd.com/hrv-and-auricular-acupuncture-in-rats/" title="Permalink to HRV and Auricular Acupuncture in Rats" rel="bookmark">HRV and Auricular Acupuncture in Rats</a></h1> <div class="entry-meta"> (info on my practice<a href="http://www.ksparrowmd.com"> here.)<br /></a><a href="http://ksparrowmd.com/hrv-and-auricular-acupuncture-in-rats/" title="08:18" rel="bookmark"><time class="entry-date" datetime="2012-04-03T08:18:06+00:00" pubdate=""></time> </a> <div class="comments-link"> </div> </div> <p>This is another Litscher study, full text article for free <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290927/?tool=pubmed">here.</a> He has done a series of articles on HRV and acupuncture which we have discussed <a href="http://ksparrowmd.blogspot.com/2010/10/austrian-study-on-acupuncture-and-heart.html">here</a>, <a href="http://ksparrowmd.blogspot.com/2010/10/austrian-acupuncture-and-hrv-study-part.html">here</a>, <a href="http://ksparrowmd.blogspot.com/2010/10/aus.html">here,</a> and <a href="http://ksparrowmd.blogspot.com/2012/03/auricular-acupuncture-for-epilepsy-case.html">here. </a> This one is the first to use animal data. It’s a combined Chinese/Austrian study in that the studies are done in China and then the data transmitted to Austria and analysed. At least that is my understanding of his work. In this study, the <a href="http://ksparrowmd.blogspot.com/2012/03/manual-acupuncture-at-st36-and-pc6.html">decrease in LFR/HFR</a> with stimulation at St36 was corroborated, albeit in rats. An overall increase in HRV was found only in ear acupuncture. ( It is amazing to me that they could even distinguish various acupunpoints on a tiny rat ear, but that was the protocol. They used the heart point, in case you’re interested.) We discussed stimulation of Stomach 36 and its effect on autonomic balance <a href="http://ksparrowmd.blogspot.com/2012/02/neuromodulation-in-gut-part-ii.html">here</a>, and <a href="http://ksparrowmd.blogspot.com/2012/03/manual-acupuncture-at-st36-and-pc6.html">here</a></p> <p> </p> <p> <a href="http://www.ncbi.nlm.nih.gov/pubmed/22454685"></a></p><blockquote><p><a href="http://www.ncbi.nlm.nih.gov/pubmed/22454685">Evid Based Complement Alternat Med. 2012;2012:817378. Epub 2012 Feb 21.<br />Sino-European transcontinental basic and clinical high-tech acupuncture studies-part 1: auricular acupuncture increases heart rate variability in anesthetized rats.</a><br />Gao XY, Liu K, Zhu B, Litscher G.<br />Source</p> <p>Department of Physiology, Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Dongzhimen Nanxiaojie Street, Beijing 100700, China.<br />Abstract</p> <p>Evidence-based research concerning the effects of high-tech acupuncture on autonomic function was performed by two research teams from China and Austria. This study describes the first transcontinental teleacupuncture measurements in animals. Heart rate (HR) and heart rate variability (HRV) recordings in 10 male Sprague-Dawley anesthetized rats were performed under stable conditions in Beijing, China, and the data analysis was completed in Graz, Austria. The electrocardiograms (ECGs) were recorded by an HRV Medilog AR12 system during acupuncture of the ear and body (PC6 Neiguan, CV12 Zhongwan, ST36 Zusanli). The data were analyzed using specially adapted novel Austrian software. HR did not change significantly during any acupuncture stimulation in anesthetized rats (ear acupuncture, PC6, CV12, or ST36). Total HRV only changed significantly (P = 0.025) during auricular acupuncture (acupoint heart). The low-frequency/high-frequency ratio parameter decreased significantly (P = 0.03) during stimulation of ST36. This change was based on intensification of the related mechanism of blood pressure regulation that has been demonstrated in previous studies in humans. Modernization of acupuncture research<br /></p></blockquote><p></p>ksparrowmdhttp://www.blogger.com/profile/06136859539406777122noreply@blogger.com0tag:blogger.com,1999:blog-6188135334037051688.post-8800917108232141732012-04-06T11:59:00.001-07:002012-04-06T12:01:38.246-07:00Do Patients Want More Care or Less?<header class="entry-header"> <h1 class="entry-title">Do Patients Want More Care or Less?</h1> <div class="entry-content"> <p>As readers of this blog know, I promote the point of view that sometimes in Medicine, Less is More. The title of my blog is “First, Do No Harm.” So this article from the NYTimes illustrating how not only patients, but physicians also are starting to see the benefit in opting to do nothing. I will emphasize a few points in the article, but those interested in this topic, please go to the link and read the whole thing. I will provide links to my previous blog posts that covered some of the topics here. (For more on my practice please click <a href="http://www.ksparrowmd.com">here.</a>)<br /></p> <blockquote><p>April 4, 2012, 4:11 pm<br /><a href="http://well.blogs.nytimes.com/2012/04/04/do-patients-want-more-care-or-less/?ref=health">Do Patients Want More Care or Less?</a></p> <p>By DAVID NEWMAN, M.D.</p> <p>…While diagnosing bronchitis, a common respiratory infection, is often easy, treating the condition is more difficult. <strong>Medicines may calm the symptoms, but the only cure is time.</strong> <strong>Most notably, antibiotics, though commonly prescribed, are no better than a placebo for bronchitis.</strong></p> <p>“Traditionally, newer and more aggressive interventions were often assumed to be better.” <strong>But there are hints of a shift, he says: “When patients are fully informed, they tend to be more conservative.”</strong></p> <p><strong>After decades of presuming that more health care leads to better health, public consciousness may be moving toward a leaner view.</strong></p> <p><strong>Today, a group of nine medical specialty boards is recommending that doctors perform 45 common tests and procedures less often, and is urging patients to question these services if they are offered.</strong> The move is the latest by the medical community to acknowledge that many tests and procedures are performed unnecessarily, leading to excessive costs, false positives, additional testing and even harm to patients. <strong>By some estimates, unnecessary treatment constitutes one third of medical spending in the United States.</strong>..</p> <p>Dr. Barry also points to news reports that may also be shifting attitudes. In just the past year, medical headlines have<strong> covered record-setting fines paid by pharmaceutical companies</strong>, the <strong>o<a href="http://ksparrowmd.blogspot.com/2009/03/americans-receive-too-much-radiation.html">veruse </a>of potentially<a href="http://ksparrowmd.blogspot.com/2010/12/radiation-risk-and-coronary-ct-scans.html"> carcinogenic medical radiation</a></strong>, <strong><a href="http://ksparrowmd.blogspot.com/2011/12/tragic-high-cost-of-failing-artificial.html">medical </a>device<a href="http://ksparrowmd.blogspot.com/2011/07/medical-device-industry-preemptively.html"> recalls</a></strong> and the <strong>rise of prescription drug deaths (which now outnumber illicit drug deaths)</strong>. Even <strong>once-sacred interventions like <a href="http://ksparrowmd.blogspot.com/2011/10/mammograms-value-still-questioned.html">screening for cancer</a> are under scrutiny, with a better understanding of both limited benefits and growing harms.</strong> That randomized trials of <a href="http://ksparrowmd.blogspot.com/2011/10/prostate-cancer-test-under-attack.html">prostate specific antigen</a> (PSA) testing, for instance,<a href="http://ksparrowmd.blogspot.com/2010/09/ongoing-controversies-in-prostate.html"> had shown </a>little or no lifesaving benefit was hardly noticed <a href="http://ksparrowmd.blogspot.com/2012/01/prostrate-screening-update-first-do-no.html">until last year</a>, when the United States Preventive Services Task Force drew attention to sexual and urinary problems and prostate biopsy complications, all common fallout from positive PSA results.</p></blockquote> </div></header>ksparrowmdhttp://www.blogger.com/profile/06136859539406777122noreply@blogger.com0tag:blogger.com,1999:blog-6188135334037051688.post-66263264427674259602012-03-31T11:46:00.001-07:002012-03-31T09:08:30.228-07:00When Less Treatment is More<span class="timestamp published" title="2012-03-29T13:23:30+00:00">An article worth reading in its entirety discussing the new guidelines for breast cancer treatment. We've discussed breast cancer treatment a few times, for example, <a href="http://ksparrowmd.blogspot.com/2011/07/blackburn-few-more-quotes-from-atlantic.html">here</a> and <a href="http://ksparrowmd.blogspot.com/2011/10/mammograms-value-still-questioned.html">here</a>. A few excerpts will follow. In the case of cancer, I can't help but wonder if our language is too clumsy. Perhaps a small "cancer" would be allowed to just be if it was called "a lump of abnormal cells." I posted about this earlier, <a href="http://ksparrowmd.blogspot.com/2011/11/whats-in-name-time-to-rename-cancer.html">here. </a>The term cancer, from the word crab, (Latin?) implies that it keeps eating away. But some of these "cancers" go away on their own, or won't cause any further damage. Incredibly difficult to change the thinking of patients or doctors at this stage of the game. It is a conversation well worth having, however. "Less is More" is the name of Dr. Redberg's blog in Annals of Internal Medicine, we've discussed <a href="http://ksparrowmd.blogspot.com/2011/11/high-resolution-ct-scans-lead-to-higher.html">here,</a> and <a href="http://ksparrowmd.blogspot.com/2010/12/some-sanity-at-last-on-statins.html">here,</a></span><blockquote><span class="timestamp published" title="2012-03-29T13:23:30+00:00"><a href="http://ksparrowmd.blogspot.com/2010/12/some-sanity-at-last-on-statins.html"></a><br />March 29, 2012, <span>1:23 pm</span></span> <h3 class="entry-title">When Less Treatment Is More</h3> <address class="byline author vcard">By <a href="http://well.blogs.nytimes.com/author/pauline-w-chen-md/" class="url fn" title="See all posts by PAULINE W. CHEN, M.D.">PAULINE W. CHEN, M.D.</a></address> <div class="entry-content"> <div class="w480">Michele Constantini<br />The path of less, versus more, treatment has met with resistance...<br /></div>“Sometimes the hardest thing for us doctors to do,” her surgeon said to me, “is to know when not to do anything.” <p>I was reminded of the relevance of his remark for both doctors and patients when I read a <a title="Journal of Clinical Oncology study." href="http://jco.ascopubs.org/content/early/2012/02/27/JCO.2011.39.4890.abstract">study on breast cancer treatment published this month</a> in The Journal of Clinical Oncology.</p> <p>For years, the standard treatment for most women with early-stage invasive breast cancer has been to cut out the tumor and then administer radiation. But eight years ago <a title="New England Journal of Medicine study." href="http://www.nejm.org/doi/full/10.1056/NEJMoa040587">in a major study</a>, that approach was re-evaluated for women over age 70. <span style="font-weight: bold;">It turned out that putting older women with less aggressive early cancers through the additional rigors and complications of radiation — fatigue, rash and the need to visit a radiation center daily for a month or more — had no effect on their survival rates.</span></p> <p>A year later, the findings were incorporated into a widely accepted <a title="National Comprehensive Cancer Network guidelines." href="http://www.nccn.org/professionals/physician_gls/pdf/breast.pdf">series of cancer treatment guidelines</a> that recommended surgery —<span style="font-weight: bold;"> but rendered radiation optional</span> — for women over 70 with more favorable early forms of breast cancer.</p> <p><span style="font-weight: bold;">But in the latest study, researchers from Yale University’s School of Medicine discovered that the earlier study and resulting recommendations have had little effect on what treatments older breast cancer patients are receiving.</span> ..<br /></p> <p style="font-weight: bold;">“We’ve become increasingly concerned about the overuse of screening tests or excessive treatments with little benefit,” said Dr. Cary P. Gross, associate professor of medicine at Yale and senior author of the study. “But these concerns aren’t reflected in changes in how we are caring for patients...”<br /></p>Patients, too, may feel the same way and insist on proceeding with treatment. Convincing them otherwise can require lengthy discussions that many doctors don’t have the time for. <span style="font-weight: bold;">“It’s almost simpler to present a ‘plan of action’ than convince a patient that doing nothing is a reasonable course,” said Dr. Kenneth B. Roberts, another one of the authors and an associate professor of therapeutic radiology at Yale.</span><p>“Our system’s ability to find new treatments has far outpaced its ability to understand the limits of those treatments or to communicate with patients about the best strategies for those treatments,” Dr. Gross said. <span style="font-weight: bold;">“What we need to do is step back and figure out how we can design our health system so that the right patient gets the right care at the right time, rather than all patients getting more care all the time.”</span></p></div></blockquote><div class="entry-content"><p><span style="font-weight: bold;"></span></p><p><span style="font-weight: bold;"><span style="font-weight: bold;">For more info on my practice click <a href="http://www.ksparrowmd.com">here.</a></span><br /></span></p> </div>ksparrowmdhttp://www.blogger.com/profile/06136859539406777122noreply@blogger.com0tag:blogger.com,1999:blog-6188135334037051688.post-26886571396641758502012-03-31T08:22:00.002-07:002012-03-31T08:34:56.376-07:00Auricular Acupuncture for Epilepsy, a Case for Vagal Stim(No posting due to travel the last two weeks, thought I could do some but I didn't see too much in the news and my schedule chaotic.)<br />I did a series of posts about Litscher's work<a href="http://ksparrowmd.blogspot.com/2010/10/austrian-study-on-acupuncture-and-heart.html"> here,</a> <a href="http://ksparrowmd.blogspot.com/2010/10/austrian-acupuncture-and-hrv-study-part.html">here</a> and <a href="http://ksparrowmd.blogspot.com/2010/10/austrian-acupuncture-and-hrv-study-part_17.html">here.</a> The abstract doesn't mention if he's looking at HRV, but I would suspect he is from his previous work. I will try to get a copy of his paper. (Sometimes it isn't possible because the abstract is out before the paper is ready.) More on my acupuncture practice <a href="http://www.ksparrowmd.com">here.<br /></a><div class="cit"><a href="http://www.ncbi.nlm.nih.gov/pubmed/22461842#" title="Evidence-based complementary and alternative medicine : eCAM."></a></div><blockquote><div class="cit"><a href="http://www.ncbi.nlm.nih.gov/pubmed/22461842#" title="Evidence-based complementary and alternative medicine : eCAM.">Evid Based Complement Alternat Med.</a> 2012;2012:615476. Epub 2012 Feb 1.</div><span style="font-weight: bold;"><br /><br />Auricular Acupuncture May Suppress Epileptic Seizures via Activating the Parasympathetic Nervous System: A Hypothesis Based on Innovative Methods.<br />He W, Rong PJ, Li L, Ben H, Zhu B, Litscher G.<br />Source<br /><br />Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.<br />Abstract<br /><br />Auricular acupuncture is a diagnostic and treatment system based on normalizing the body's dysfunction. An increasing number of studies have demonstrated that auricular acupuncture has a significant effect on inducing parasympathetic tone. Epilepsy is a neurological disorder consisting of recurrent seizures resulting from excessive, uncontrolled electrical activity in the brain. Autonomic imbalance demonstrating an increased sympathetic activity and a reduced parasympathetic activation is involved in the development and progress of epileptic seizures. Activation of the parasympathetic nervous system such as vagus nerve stimulation has been used for the treatment of intractable epilepsy. Here, we propose that auricular acupuncture may suppress epileptic seizures via activating the parasympathetic nervous system.</span><br /></blockquote>ksparrowmdhttp://www.blogger.com/profile/06136859539406777122noreply@blogger.com0tag:blogger.com,1999:blog-6188135334037051688.post-74903296119881979382012-03-17T08:46:00.003-07:002012-03-17T08:56:11.038-07:00Fewer Pap Smears RecommendedI offer this up as part of an emerging trend in the prevention world. It seems that there is a <span style="font-weight: bold;">dawning realization that more treatment, more intervention, does not always lead to better outcomes</span>. It might shock many patients to realize that, for example, HPV (human papilloma virus) is eliminated in most cases by the patient's own immune system and won't cause any problems. Just as some breast cancers are small and will go away and the treatment might be worse than any outcome of letting the cancers be. This is a "hard sell" after so many years of admonishing people to get screened for all sorts of conditions. More on my practice, <a href="http://www.ksparrowmd.com">here.<br /></a><blockquote>March 14, 2012, 5:58 pm<br />New Guidelines Advise Less Frequent Pap Smears<br />By TARA PARKER-POPE<br /><br />The annual Pap smear, a cornerstone of women’s health for at least 60 years, is now officially a thing of the past, as new national guidelines recommend cervical cancer screening no more often than every three years.<br /><br />In recent years, some doctors and medical groups, including the American College of Obstetricians and Gynecologists in 2009, began urging less frequent screening for cervical cancer. Even so, annual Pap smear testing is still common because many women are reluctant to give up frequent screening for cervical cancer...<br /><br />“We achieve essentially the same effectiveness in the reduction of cancer deaths, but we reduce potential harm of false positive tests,” said Dr. Wanda Nicholson, a task force member and an associate professor of obstetrics and gynecology at the University of North Carolina at Chapel Hill. “It’s a win-win for women.”<br /><br />Cost is not a factor in the task force recommendations. Instead, its members focus on the effectiveness of a screening test to reduce cancer deaths, balanced against the potential harms that accompany the screening. <span style="font-weight: bold;">The worry about frequent Pap smear screening is that tests can result in a large number of false positives that lead to sometimes painful biopsies and put women at risk for pregnancy complications in the future, like preterm labor and low-birth-weight infants...</span><br /><br />Finally, the group also recommends against regular HPV screening for anyone under 30. In 2003, the task force said it did not have enough evidence to make a recommendation about HPV testing.<span style="font-weight: bold;"> It now says the test is unnecessary because many women exposed to the virus will eventually eliminate the virus without any intervention.</span><br /><br /><span style="font-weight: bold;">“HPV in women under 30 is highly prevalent but also highly transient,” Dr. Nicholson said. “Women under 30 may get infected with HPV, but they have a high likelihood of clearing that infection on their own, and it not causing any long-term change to their cervical tissue.”</span><br /><br /><br /></blockquote>ksparrowmdhttp://www.blogger.com/profile/06136859539406777122noreply@blogger.com0tag:blogger.com,1999:blog-6188135334037051688.post-90355606376696348102012-03-14T09:33:00.006-07:002012-03-14T10:23:21.715-07:00Do Statins Make It Tough to Exercise?: More Statin ProblemsTo be tossed into the "First Do No Harm" file. I don't know what to make of the rat study, but it still amazes me that statins are the most widely prescribed drugs in the world. I've discussed some of the problems with statins, <a href="http://ksparrowmd.blogspot.com/2011/06/cholesterol-drugs-statins-linked-with.html">diabetes risk here</a>, <a href="http://ksparrowmd.blogspot.com/2012/03/statins-good-for-you-think-again-fda.html">cognition problems here,</a> and <a href="http://ksparrowmd.blogspot.com/search?q=sanity+on+statins">here.</a> Link to the article if you are on statins, or know someone who is.<blockquote><br />March 14, 2012, 12:01 am<br /><a href="http://well.blogs.nytimes.com/2012/03/14/do-statins-make-it-tough-to-exercise/?pagemode=print">Do Statins Make It Tough to Exercise?</a><br />By GRETCHEN REYNOLDS<br /><br />For years, physicians and scientists have been aware that statins, the most widely prescribed drugs in the world, can cause muscle aches and fatigue in some patients. <span style="font-weight: bold;">What many people don’t know is that these side effects are especially pronounced in people who exercise.</span><br /><br />To learn more about the effect statins have on exercising muscles, scientists in Strasbourg, France, recently gave the cholesterol-lowering drug Lipitor to a group of rats for two weeks, while a separate control group was not medicated. Some of the rats from both groups ran on little treadmills until they were exhausted.<br /><br />It was immediately obvious that the medicated animals couldn’t run as far. They became exhausted much earlier than the rats that had not been given statins...<br /><br /><br /><span style="font-weight: bold;">Statins’ safety has come under considerable scrutiny in recent weeks. Last month, the Food and Drug Administration added safety alerts to prescribing information for statins, warning of risks for memory loss and diabetes, as well as muscle pain.</span><br /><br />More than 20 million Americans are taking statins, and by most estimates, at least 10 percent of them will experience some degree of muscle achiness or fatigue. <span style="font-weight: bold;">That proportion rises to at least 25 percent among people taking statins who regularly exercise, and may be 75 percent or higher among competitive athletes...</span><br /><br />“Statins are anti-aging for arteries,” he says. <span style="font-style: italic;">“If you take them, you’ll have younger arteries. Unfortunately,” he adds, “they are not anti-aging for muscles.”</span><br /></blockquote><br />More information about my practice <a href="http://www.ksparrowmd.com/">here. </a>ksparrowmdhttp://www.blogger.com/profile/06136859539406777122noreply@blogger.com0tag:blogger.com,1999:blog-6188135334037051688.post-30747202439676623902012-03-12T09:38:00.000-07:002012-03-12T09:38:39.855-07:00Exercise Fueling the BrainFrom the NYTimes an article on how exercise improves brain functioning. This could be part of the anti-aging aspect to exercise. (More info on my practice <a href="http://www.ksparrowmd.com/">here.)</a><br /><blockquote><br /><a href="http://well.blogs.nytimes.com/2012/02/22/how-exercise-fuels-the-brain/?pagemode=print">How Exercise Fuels the Brain</a><br />By GRETCHEN REYNOLDS<br />Moving the body demands a lot from the brain...<br />This increase in brain activity naturally increases the brain’s need for nutrients, but until recently, scientists hadn’t fully understood how neurons fuel themselves during exercise. Now a series of animal studies from Japan suggest that the exercising brain has unique methods of keeping itself fueled. <span style="font-weight: bold;">What’s more, the finely honed energy balance that occurs in the brain appears to have implications not only for how well the brain functions during exercise, but also for how well our thinking and memory work the rest of the time.</span>..<br />But about 10 years ago, some neuroscientists found that specialized cells in the brain, known as <span style="font-weight: bold;">astrocytes, that act as support cells for neurons actually contained small stores of glycogen, or stored carbohydrates. And glycogen, as it turns out, is critical for the health of cells throughout the brain.</span><br /><br />While a brain with more fuel reserves is potentially a brain that can sustain and direct movement longer, it also “may be a key mechanism underlying exercise-enhanced cognitive function,” says Hideaki Soya, a professor of exercise biochemistry at the University of Tsukuba and senior author of the studies, since supercompensation occurs most strikingly in the parts of the brain that allow us better to think and to remember. As a result, Dr. Soya says, <span style="font-weight: bold;">“it is tempting to suggest that increased storage and utility of brain glycogen in the cortex and hippocampus might be involved in the development” of a better, sharper brain.</span>..<br /><span style="font-weight: bold;">He and his colleagues have found that “glycogen supercompensation in some brain loci” is “enhanced in rats receiving carbohydrates immediately after exhaustive exercise.” So for people, that might mean that after a run or other exercise that is prolonged or strenuous enough to leave you tired, a bottle of chocolate milk or a banana might be just the thing your brain is needing.</span><br /></blockquote>ksparrowmdhttp://www.blogger.com/profile/06136859539406777122noreply@blogger.com0tag:blogger.com,1999:blog-6188135334037051688.post-64429743996607238622012-03-11T16:00:00.000-07:002012-03-11T11:03:53.473-07:00Electroacupuncture, Immunity and Autonomic Nervous System in RatsWe've seen a number of studies on acupuncture and the immune system and its effect on cellular immunity(<a href="http://ksparrowmd.blogspot.com/2011/07/notes-from-ngf-nerve-growth-factor-and.html"><span style="font-style: italic;">Nerve growth factor and electroacupuncture)</span></a>, <a href="http://ksparrowmd.blogspot.com/2011/01/moxibustion-activates-host-defense.html">moxabustion and cytokine production</a>, <a href="http://ksparrowmd.blogspot.com/2012/01/acupuncture-for-eczema-role-of.html">basophils and acupuncture for eczema</a>, and some theoretical studies on <a href="http://ksparrowmd.blogspot.com/2011/01/acupuncture-in-elderly-to-attenuate.html">stress and immunity </a>but I don't recall seeing a paper drawing the specific connection between the autonomic nervous system and improved immunity. In rats no less... (Information about my practice <a href="http://www.ksparrowmd.com/">here.</a>)<br /><a href="http://www.ncbi.nlm.nih.gov/pubmed/22222470"></a><blockquote><a href="http://www.ncbi.nlm.nih.gov/pubmed/22222470">Anesthesiology. 2012 Feb;116(2):406-14.</a><br /><span style="font-weight: bold;">Electroacupuncture improves survival in rats with lethal endotoxemia via the autonomic nervous system.</span><br /><span style="font-style: italic;font-size:85%;" >Song J</span><span style="font-size:85%;"><span style="font-style: italic;">G, Li HH, Cao YF, Lv X, Zhang P, Li YS, Zheng YJ, Li Q, Yin PH, Song SL, Wang HY, Wang XR.</span></span><br /><span style="font-size:85%;"><span style="font-style: italic;">Department of Anesthesiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.</span></span><br />Recent advances have indicated a complex interplay between the autonomic nervous system and the innate immune system. <span style="font-weight: bold;">Targeting neural networks for the treatment of sepsis is being developed as a therapeutic strategy.</span> Because electroacupuncture at select acupoints can modulate activities of the autonomic nervous system, we<span style="font-weight: bold;"> tested the hypothesis that electroacupuncture at specific acupoints could modulate systemic inflammatory responses and improve survival via its impact on the autonomic nervous system in a rat model of sepsis.</span><br />METHODS:<br /><br />Sprague-Dawley male rats received electroacupuncture for 45 min before and at 1, 2, or 4 h after a lethal dose of intraperitoneal lipopolysaccharide injection (6 mg/kg). Outcomes included <span style="font-weight: bold;">survival </span>and<span style="font-weight: bold;"> systemic cytokine response</span>s. Also, the possible roles of <span style="font-weight: bold;">neural circuitry, </span>including the h<span style="font-weight: bold;">ypothalamic-pituitary-adrenal axis and the autonomic nervous system</span>, were evaluated.<br />RESULTS:<br />Electroacupuncture pretreatment at the Hegu acupoints significantly attenuate systemic inflammatory responses and improve survival rate from 20% to 80% in rats with lethal endotoxemia. Such a site-specific effect requires the<span style="font-weight: bold;"> activation of muscarinic receptors in the central nervous system, but not increasing central sympathetic tone.</span> In the periphery synergistic, rather than independent, action of the sympathetic and parasympathetic systems is also necessary.<br />CONCLUSIONS:<br /><span style="font-weight: bold;">Electroacupuncture pretreatment has a dramatic survival-enhancing effect in rats with lethal endotoxemia, which involves the activation of efferent neural circuits of the autonomic nervous system (e.g., cholinergic antiinflammatory pathway).</span> This approach could be developed as a prophylactic treatment for sepsis or perioperative conditions related to excessive inflammation.</blockquote>ksparrowmdhttp://www.blogger.com/profile/06136859539406777122noreply@blogger.com0tag:blogger.com,1999:blog-6188135334037051688.post-55587442238368505182012-03-11T10:19:00.003-07:002012-03-11T10:42:40.354-07:00More Acupuncture and HRV: Systems Level ApproachTo be filed under "Couldn't Have Said It Better Myself." I'm pleased that there is more interest in HRV and acupuncture since I've been studying this topic for <a href="http://ksparrowmd.com/san-francisco-acupuncture-research.htm">10 years. </a> I've ordered a new HRV monitoring system from Vivonoetics (vivonoetics.com) which should be arriving this coming week. Yay! I was struggling to get my J and J system to work, so am hopeful that a new system should make data gathering much easier. More information about my practice <a href="http://www.ksparrowmd.com/">here.<br /></a><a href="http://www.ncbi.nlm.nih.gov/pubmed/22385564"></a><blockquote><a href="http://www.ncbi.nlm.nih.gov/pubmed/22385564">Explore (NY). 2012 Mar;8(2):99-106.</a><br /><span style="font-weight: bold;">Acupuncture and heart rate variability: a systems level approach to understanding mechanism.</span><br /><span style="font-size:85%;"><span style="font-style: italic;">Anderson B, Nielsen A, McKee D, Jeffres A, Kligler B.</span></span><br /><span style="font-size:85%;"><span style="font-style: italic;">Pacific College of Oriental Medicine, New York, NY; Albert Einstein College of Medicine, Yeshiva University, Bronx, NY.</span></span><br />Abstract<br /><br />Recent research has elucidated several different mechanisms for acupuncture. However, the interrelationship between these mechanisms and how acupuncture affects complex physiological systems is still not understood. Heart rate Variability (HRV), the beat-to-beat fluctuations in the rhythm of the heart, results from the regulation of the heart by the autonomic nervous system (ANS). Low HRV is associated with increased risk of all-cause mortality and is a marker for a wide range of diseases. Coherent HRV patterns are associated with increased synchronization between the two branches of the ANS, and when sustained for long periods of time result in increased synchronization and entrainment between multiple body systems. There is strong evidence from randomized placebo controlled trials that acupuncture modulates HRV. This may represent a mechanistic pathway for global physiological regulation, which is congruent with East Asian medical theory. The ability of acupuncture to improve HRV could be used as a tool in acupuncture research and practice to monitor treatment effectiveness and the impact on quality of life.</blockquote>ksparrowmdhttp://www.blogger.com/profile/06136859539406777122noreply@blogger.com0